Metformin use associated with reduced risk of frailty in diabetes patients
China: A study published in the European Journal of Medical Research has concluded that metformin use is independently associated with lower frailty risk in diabetic patients.
Metformin is also protective against age-related musculoskeletal disorders. Early identification and timely intervention of the frailty can enhance metformin benefits.
Diabetes is an independent risk factor for frailty. The condition causes increased adverse outcomes in diabetic patients. Metformin is a commonly used antidiabetic drug. The two mechanisms of diabetes and frailty are Insulin resistance and chronic inflammation. These are the main targets of metformin.
Metformin has anti-ageing potential, says research. A previous study has mentioned that using metformin improves the mean walking speed in pre-frail older patients without any history of diabetes.
There needs to be more data on the relationship between metformin and frailty. Researchers explored this association in a study. The frailty was defined as the Fried phenotype.
The study summary includes the following:
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