Microvascular complications of diabetes linked to pancreatic cancer
CHINA: According to a study published in the Journal of the Endocrine Society, early-stage chronic kidney disease, a microvascular complication of Diabtetes Mellitus Type 2, substantially predicted pancreatic cancer (PaC), but not the macrovascular complications.
A major public health issue, diabetes mellitus (DM) affects around 463 million people globally at this time. Numerous microvascular and macrovascular problems have long been linked to DM. The correlation between DM and various tumors has received increased attention in recent years. Although pancreatic cancer (PaC) and diabetes mellitus (DM) are related, few extensive studies have looked into the predictive risk factors for PaC.
In a retrospective cohort study spanning the entire region, the current study sought to investigate the predictors for PaC in individuals with type 2 diabetes mellitus (T2DM).
Retrospective cohort studies of T2DM mellitus patients older than 40 without a history of PaC were conducted throughout the territory to achieve this objective. Biochemical data, comorbidities, use of antidiabetic medicines, and baseline demographics were retrieved. Hazard ratios (HR) with 95% CI were calculated using Cox regression. On the basis of the phases of chronic kidney disease (CKD), subgroup analyses were conducted. The sample size for this study was 2,73,738 patients, of whom 1148 acquired PaC (age = 65.4 12.7 years; males made up 48.2%; follow-up time = 3547 1207 days; disease duration = 4.8 2.3 years).
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