More favorable modifiable factors score promotes return of blood sugar status from prediabetes to normoglycemia

"Prediabetes glycemic status may be reversible, and having a more favorable modifiable factors score may promote the change blood sugar status from prediabetes to normoglycemia." the researchers wrote in their study.

Prediabetes is a critical condition that often progresses to type 2 diabetes (T2D) but is also potentially reversible. Thus, knowing the determinants that may be important for changing prediabetes blood sugar status is critical. However, only a few population-based studies have included modifiable factors to find out their association with changes in glycemic status from diabetes.

Against the above background, Ji-Yeob Choi from Seoul National University College of Medicine in Seoul, Republic of Korea, and colleagues aimed to investigate the associations between modifiable risk factors and blood sugar status changes in people with prediabetes.

The study included 10,358 individuals with prediabetes defined by their HbA1c and fasting blood glucose levels from the Health Examinees-Gem study. Modifiable factors, including abdominal obesity, BMI, physical activity, smoking status, hypertension, diet quality, dyslipidemia, and alcohol consumption, were examined to determine their associations with changes in glycemic status during follow-up. They also analyzed the association of modifiable factor scores with changes in glycemic status. The median follow-up time for the study was four years.

The study outcomes included prediabetes existence, diabetes progression, and normoglycemia reversion.

The study led to the following findings:

• BMI ≥25 kg/m2 (adjusted odds ratio [OR] 0.71), abdominal obesity (OR 0.76), heavy drinking (OR 0.74), hypertension (OR 0.71), and dyslipidemia (OR 0.78) were linked with a lower possibility of normoglycemia reversion. BMI ≥25 kg/m2 (OR 1.58), abdominal obesity (OR 1.31), current smoking (OR 1.43), and hypertension (OR 1.26) were associated with a higher probability of type 2 diabetes progression.
• More favourable modifiable factors were also associated with normoglycemia reversion (OR 1.46) and type 2 diabetes progression (OR 0.62).

The researchers conclude, "more favorable modifiable factors are linked to a higher odds of returning to normoglycemia and a lower likelihood of progression to type 2 diabetes."

Reference:

Salma Nabila, Ji-Eun Kim, Jaesung Choi, JooYong Park, Aesun Shin, Sang-Ah Lee, Jong-koo Lee, Daehee Kang, Ji-Yeob Choi; Associations Between Modifiable Risk Factors and Changes in Glycemic Status Among Individuals With Prediabetes. Diabetes Care 2023; dc221042. https://doi.org/10.2337/dc22-1042