New study discovers a novel technique for glucose delivery
In a new study, published in the Journal of the American Chemical Society, the traditional use of glucagon is preferred as a preventive measure than its previous emergency use.
Nature achieves remarkable function from the formation of transient, nonequilibrium materials realized through continuous energy input. The role of enzymes in catalysing chemical transformations to drive such processes, often as part of stimuli-directed signalling governs both material formation and lifetime.
In this study a group of researchers from U.S.A demonstrate how they successfully developed hydrogels that remain intact in the presence of glucose but slowly destabilize as levels drop, releasing glucagon into the system, raising glucose levels.
The researchers found that as compared to traditional glucose-responsive materials, which typically engineer degradation to release insulin under high-glucose conditions, the transient nano fibrillar hydrogel materials here get stabilized in the presence of glucose but destabilized under conditions of limited glucose to release encapsulated glucagon.
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