New test may help in early diagnosis of Cushing's Syndrome: Frontiers
Hypercortisolism is responsible for significant morbidity and mortality and is frequently a diagnostic challenge for clinicians. To treat Cushing's syndrome (CS) as soon as feasible, a rapid diagnosis is required.
A simple measure, the Cushing score, was created and internally validated in a new study to evaluate pre-test likelihood of hypercortisolism, and it has shown outstanding predictive value for the discriminating between people with and without a final diagnosis of Cushing's disease.
This study was conducted by Mirko Parasiliti-Caprino and team with the objective to create and evaluate a clinical model for estimating the pre-test likelihood of hypercortisolism in a high-risk group. The findings of this study were published in Frontiers in Endocrinology on 5th October, 2021.
Researchers performed a retrospective multicenter case-control study comprising five Italian Endocrinology referral facilities for this investigation (Turin, Messina, Naples, Padua and Rome). A total of 150 patients with Cushing's syndrome and 300 patients without hypercortisolism were included in the study. All patients were assessed for the possibility of hypercortisolism in accordance with current recommendations. The Cushing score was developed using multivariable logistic regression, with all major variables linked with a clinical suspicion of hypercortisolism included as potential predictors. A stepwise backward selection approach was utilized (final model AUC=0.873), followed by ten-fold cross-validation for internal validation.
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