Nocturnal Hypoglycemia common in ICU discharged Insulin Dependent T2D Patients: Study
In the ICU, hypoglycemia occurs more often with intensive insulin therapy and is associated with increased mortality. In a recent study, researchers have reported that the risk of hypoglycemia, predominantly at night, is common in ICU discharged insulin-dependent type 2 diabetic patients. The study findings were published in the journal Critical Care Medicine in April 2021 issue.
Several studies have evaluated the risk of hypoglycemia in hospitalized and critically ill patients. However, there is limited information about glycemic control after discharge from the ICU. Therefore, Dr Ali Abdelhamid, Yasmine and her team conducted a study to evaluate the prevalence of hypoglycemia in ICU survivors with type-2 diabetes and determine whether hypoglycemia is associated with cardiac arrhythmias.
It was a prospective, observational, two-centre study of 31 with type-2 diabetes who were discharged from ICU after greater than or equal to 24 hours with greater than or equal to one organ failure and were prescribed subcutaneous insulin. The participants underwent up to 5 days of simultaneous blinded continuous interstitial glucose monitoring and ambulatory 12-lead electrocardiogram monitoring immediately after ICU discharge during ward-based care. The researchers monitored the frequency of arrhythmias, heart rate variability, and cardiac repolarization markers, and compared them between hypoglycemia (interstitial glucose ≤ 3.5 mmol/L) and euglycemia (5–10 mmol/L) matched for the time of day. They monitored the patients for101 ± 32 hours post-ICU.
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