Nocturnal Hypoglycemia common in ICU discharged Insulin Dependent T2D Patients: Study

It was a prospective, observational, two-centre study of 31 with type-2 diabetes who were discharged from ICU after greater than or equal to 24 hours with greater than or equal to one organ failure and were prescribed subcutaneous insulin. The participants underwent up to 5 days of simultaneous blinded continuous interstitial glucose monitoring and ambulatory 12-lead electrocardiogram monitoring immediately after ICU discharge during ward-based care. The researchers monitored the frequency of arrhythmias, heart rate variability, and cardiac repolarization markers, and compared them between hypoglycemia (interstitial glucose ≤ 3.5 mmol/L) and euglycemia (5–10 mmol/L) matched for the time of day. They monitored the patients for101 ± 32 hours post-ICU.

Key findings of the study were:

• Upon evaluation, the researchers observed hypoglycemia events in 12 participants (39%) and noted that it was predominantly nocturnal (40/51 hr) and asymptomatic (25/29 episodes).
• They noted that participants experiencing hypoglycemia had 2.4 ± 0.7 discrete episodes lasting 45 minutes (interquartile range, 25–140 min).
• They also noted that glucose nadir was less than or equal to 2.2 mmol/L in 34% of episodes.
• They mentioned that the longest episode of nocturnal hypoglycemia was 585 minutes with glucose nadir less than 2.2 mmol/L.
• They obtained a simultaneous electrocardiogram and continuous interstitial glucose monitoring recordings during 44 hours of hypoglycemia and 991 hours of euglycemia.
• They further found that hypoglycemia was associated with a greater risk of bradycardia but did not affect atrial or ventricular ectopics, heart rate variability, or cardiac repolarization.

The authors concluded, "In ICU survivors with insulin-treated type-2 diabetes, hypoglycemia occurs frequently and is predominantly nocturnal, asymptomatic, and prolonged."

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DOI: 10.1097/CCM.0000000000004810