DFUD is a long-standing, life-changing diabetic complication that is frequently under-diagnosed with regard to its catastrophizing effects. Previously, almost all risk factor information was derived from small, clinic-based surveys that tended to be cross-sectional in design. The current study sought to address the deficit through the utilization of two large and independent English and Scottish diabetic cohorts, providing one of the largest analyses to date.
The research evaluated a combined total of 391,790 individuals with diabetes—131,042 from England via the Clinical Practice Research Datalink (CPRD), and 260,748 from Scotland via the Scottish Diabetes Research Network-National Diabetes Dataset (SDRN-NDS). The English cohort included primary and secondary care data, whereas the Scottish cohort utilized secondary care and foot clinic data.
Key Findings
Incidence of DFUD:
• In the English cohort, 4.7% of patients developed DFUD during a median follow-up of 4.3 years, representing an incidence rate of 9.0 per 1,000 person-years (95% CI: 8.8–9.2).
• In the Scottish cohort, 2.9% of patients developed DFUD during a median follow-up of 6.3 years, with an incidence rate of 4.4 per 1,000 person-years (95% CI: 4.3–4.5).
Common Risk Factors Identified in Both Populations:
• Age: The older patients had higher chances of developing DFUD.
• Sex: Males were more vulnerable.
• Ethnicity: Individuals of White ethnicity were having greater incidence rates.
• Lifestyle: Smokers were much more likely to develop DFUD.
• Clinical indicators: Greater systolic blood pressure and baseline HbA1c levels were strongly related with subsequent DFUD.
This study provides strong evidence to support the targeting of these high-risk groups in diabetes care programs. These findings can provide the impetus for more effective prevention strategies, lowering the life-changing costs of diabetic foot ulcer disease.
Reference:
Gharibzadeh S, Lee J, Highton P, Greenlaw N, Gillies C, Zaccardi F, Brennan A, Pollard DJ, Valabhji J, Game F, Stanley B, Leese G, Gray L, Tesfaye S, Webb D, Wild S, Shabnam S, Davies M, Khunti K, Petrie J, Gregg E. Risk factors for development of diabetic foot ulcer disease in two large contemporary UK cohorts. Diabetes Obes Metab. 2025 Jun 24. doi: 10.1111/dom.16519. Epub ahead of print. PMID: 40555701.
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