Olfactory dysfunction predictor of dementia in elderly with diabetes, Study says

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2021-04-23 01:45 GMT | Update On 2021-04-23 05:04 GMT

Researchers from the Department of Metabolism & Endocrinology, Tokyo, Japan have recently observed that olfactory dysfunction precedes the development of probable dementia in older patients with type 2 diabetes.

The study is published in the Diabetes Research and Clinical Practice.

Patients with type 2 diabetes are generally reported to have olfactory dysfunction. While the underlying mechanism of olfactory dysfunction in patients with type 2 diabetes remains unclear, hyperglycemia and insulin resistance may be involved in the development of olfactory dysfunction.

Thus, even though we have previously demonstrated an association between olfactory dysfunction and cognitive impairment in older patients with type 2 diabetes, it remains largely unknown whether olfactory dysfunction could be an early marker of future cognitive impairment in patients with type 2 diabetes.

Therefore, Haruna Sanke and colleagues carried out the present study with the aim to investigate whether olfactory dysfunction could be an early marker of future dementia in older patients with type 2 diabetes.

This exploratory study included 151 older Japanese outpatients with type 2 diabetes who did not have a diagnosis of probable dementia at baseline. A multivariate logistic regression model was used to determine whether Open Essence (OE) test score at baseline is associated with the development of probable dementia.

The results showed that-

Over 3 years, approximately 9% of the study subjects developed probable dementia.

Subjects with olfactory dysfunction at baseline developed probable dementia more frequently than those without.
Multivariate logistic regression showed that lower OE test score, higher age, lower Mini-Mental State Examination (MMSE) score, higher total protein concentration, and more frequent use of a sulfonylurea are significantly associated with the development of probable dementia.
Stepwise multivariate regression analysis demonstrated that change in OE test score over 3 years is significantly associated with change in MMSE score.

Hence, the authors concluded that "olfactory dysfunction precedes the development of probable dementia in older patients with type 2 diabetes."

Article Source : Diabetes Research and Clinical Practice

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Dr. Nandita Mohan

Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

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Olfactory dysfunction predictor of dementia in elderly with diabetes, Study says

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