Once-Weekly Insulin as effective as once-daily insulin in type 2 Diabetes: NEJM
Researchers have found that Once-weekly treatment with insulin icodec had blood sugar lowering efficacy and a safety profile similar to those of once-daily insulin glargine U100 in patients with type 2 diabetes, according to a study published in the New England Journal of Medicine.
It is quite often put to thought that decreased frequency of basal insulin injections might facilitate treatment acceptance and adherence among patients with type 2 diabetes. Insulin icodec is a basal insulin analog designed for once-weekly administration that is in development for the treatment of diabetes.
Hence, the authors conducted a 26-week, randomized, double-blind, double-dummy, phase 2 trial on a total of 247 participants who all were randomly assigned (1:1) to receive either icodec or glargine. The study aimed to investigate the efficacy and safety of once-weekly insulin icodec as compared with once-daily insulin glargine U100 in patients who had not previously received long-term insulin treatment and whose type 2 diabetes was inadequately controlled while taking metformin with or without a dipeptidyl peptidase 4 inhibitor.
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