PFAS Exposure tied with Weaker Bones in Teen Boys: Study
PFAS Exposure is tied with Weaker Bones in Teen Boys, according to a recent study published in The Journal of Clinical Endocrinology & Metabolism.
Per- and polyfluoroalkyl substances (PFAS) and phthalates are two families of environmental endocrine disruptors that may be associated with areal lower bone mineral density (aBMD).
A study examined associations between serum PFAS and urinary phthalate biomarker concentrations and their mixtures with aBMD Z-score in adolescents.
They examined serial cross-sectional data from male (n=453) and female (n=395) 12-19 year old participants in the 2011—2016 National Health and Nutrition Examination Survey with measures of serum PFAS, urinary phthalate metabolites, and dual-energy X-ray absorptiometry aBMD Z-score (total body less head). In sex-specific models, we used linear regression to examine associations of individual PFAS and phthalate biomarkers with aBMD Z-score, and Bayesian kernel machine regression (BKMR) to examine the association of the overall PFAS/phthalate biomarker mixture with aBMD Z-score. We replicated the analysis, stratifying by race/ethnicity.
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