Poor Glycemic Control linked to reduced plateletcrit and platelet mass levels among children: Study on Platelet Levels in Pediatric Diabetes

For this purpose, the researchers conducted a retrospective study. They used glycated hemoglobin (HbA1c) values to categorize patients as <7% (good) and ≥7% (poor). The platelet mass value was calculated from the hemogram data (PM=PLTxMPV).

The study revealed the following findings:

• The study included eighty-seven patients diagnosed with T1DM and 120 healthy participants.
• Fasting glucose, urea, creatinine, hemoglobin (HGB), red blood cell (RBC), mean platelet volume, and platelet distribution width were significantly higher in the patient group than in the healthy control group.
• Platelet, plateletcrit, and PM were significantly lower in the poor glycemic control group than in the good glycemic control and healthy groups.
• The PDW in the healthy control group was statistically significantly lower than in the good and poor glycemic control groups. In the group with poor glycemic control, there was a positive and significant correlation between the MPV and the level of HbA1c (r=0.401).

"Additional research is necessary to investigate whether the reduction in platelet (PLT) levels is attributed to increased platelet hyperactivity and accelerated turnover. Furthermore, there is a need to elucidate how platelet indices influence the course and complications of diabetes," the researchers concluded.

Reference:

Yucel K, Disci SI, Yucel M. Effect of Glycemic Control on Platelet Indices in Children with Type 1 Diabetes Mellitus.Med Bull Sisli Etfal Hosp 2024;58(2):139–145