Prevalence of Erectile dysfunction high among men with prediabetes and diabetes, finds study

A study was done to determine the burden and identify correlates of erectile dysfunction (ED) among men with prediabetes (PreD) and type 2 diabetes (T2D) enrolled in the Diabetes Prevention Program (DPP) Outcomes Study (DPPOS). The 2017 DPPOS visit included the administration of the International Index of Erectile Function. Of 648 male participants, 88 % (n = 568) completed the survey. Associations between sociodemographic, behavioural, clinical, and glycemic measures at the time of erectile dysfunction assessment and erectile dysfunction were examined using multivariable logistic regression models in men with prediabetes and type 2 diabetes separately. Results: Overall, 218 (38 %) men met erectile dysfunction criteria. Prevalence was similar in men with prediabetes (41 %) and type 2 diabetes (37 %) (p = 0.4). In all men, age (p < 0.001) increased the odds of erectile dysfunction. Among men with PreD, those assigned to intensive lifestyle intervention (ILS), but not metformin, had decreased odds of erectile dysfunction compared with the placebo group. Non-Hispanic White race was associated with increased odds of Erectile dysfunction compared with other races. Among men with type 2 diabetes, Erectile dysfunction risk did not differ by DPP treatment assignment; however, individuals with metabolic syndrome defined by National Cholesterol Education Program criteria, had increased odds of Erectile dysfunction, as did individuals with depression. Erectile dysfunction is prevalent in men with prediabetes and type 2 diabetes. The finding of reduced odds of erectile dysfunction in men randomized to ILS and with prediabetes suggests a potential opportunity for risk mitigation in the prediabetes interval. In men who have progressed to type 2 diabetes, metabolic factors appear to be associated with erectile dysfunction.

Yooni A. Blair, Lindsay Doherty, Marinella Temprosa, Rodica Pop-Busui, Kishore M. Gadde, Prachi Singh, Arthur H. Owora, Hunter Wessells, Aruna V. Sarma. Prevalence and predictors of erectile dysfunction among men in the diabetes prevention program outcomes study, Journal of Diabetes and its Complications, Volume 38, Issue 2, 2024, 108669, ISSN 1056-8727, https://doi.org/10.1016/j.jdiacomp.2023.108669.

(https://www.sciencedirect.com/science/article/pii/S1056872723002672)

Keywords:

Prevalence of ED, men and erectile dysfunction, prediabetes, diabetes, Journal of Diabetes and its Complications, Prediabetes; Diabetes; Erectile dysfunction, Yooni A. Blair, Lindsay Doherty, Marinella Temprosa, Rodica Pop-Busui, Kishore M. Gadde, Prachi Singh, Arthur H. Owora