Regular and prolonged use of PPIs associated with higher risk of diabetes: Study
Regular and prolonged use of PPIs is associated with a higher risk of diabetes, according to a recent study published in The Journal of Clinical Endocrinology & Metabolism.
It is still debated whether prolonged use of proton pump inhibitors (PPIs) might affect metabolic health. A study was conducted to investigate the relationship between prolonged use of PPIs and the risk of developing diabetes.
Researchers performed a case-control study nested into a cohort of 777,420 patients newly treated with PPIs between 2010 and 2015 in Lombardy, Italy. A total of 50,535 cases diagnosed with diabetes until 2020 were matched with an equal number of controls that were randomly selected from the cohort members according to age, sex, and clinical status. Exposure to treatment with PPIs was assessed in case-control pairs based on the time of therapy. A conditional logistic regression model was fitted to estimate the odds ratios (OR) and 95% confidence intervals (CI) for the exposure-outcome association, after adjusting for several covariates. Sensitivity analyses were performed to evaluate the robustness of our findings.
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