Renal function deterioration among diabetes patients strongly linked to HF hospitalization

FRANCE: Beyond baseline eGFR, renal function deterioration was a major and independent risk factor linked to the development of heart failure hospitalization (HFH) in people with type 2 diabetes, states a study published in the journal, Diabetes Research and Clinical Practice.

Globally, the prevalence of diabetes is rising, and by 2030, more than 10% of people will have the disease. A recent large meta-analysis involving over 12 million people showed that those with diabetes have twice as high chance of developing heart failure than people without it. Additionally, a recent revelation showed that among those with type 2 diabetes, the incidence of heart failure hospitalization (HFH) is comparable to that of myocardial infarction.

The researchers of this study evaluated the relationship between heart failure hospitalization (HFH) and renal function deterioration in people with type 2 diabetes and established dynamic HFH predictions (DynHFH) based on repeated estimated glomerular filtration rate (eGFR) data.

1413 patients from the SURDIAGENE cohort were investigated. From 2002 to 2012, participants were registered at the University Hospital of Poitiers (France). The criteria for inclusion, included having type 2 diabetes without end-stage kidney disease (ESKD), which is indicated by the requirement for ongoing renal replacement treatment and/or an eGFR below 15 ml/min/1.73 m2. They determined the likelihood of remaining HFH-free in the following five years using a joint model for longitudinal CKD-EPI measurements and HFH risk.