Risk score may predict risk of major adverse limb events in diabetes patients: Study
USA: A risk score may identify patients with type 2 diabetes (T2D) at high risk for major adverse limb events (MALE) including those without a history of peripheral artery disease (PAD), according to a recent study in the journal Diabetic Medicine. MALE included gangrene, revascularization and amputation.
Models that predict amputation in people with T2D with foot ulceration or infection do exist, E. Hope Weissler, Duke University School of Medicine, Durham, NC, USA, and colleagues aimed to develop a predictuon model for a broader range of MALE among people with type 2 diabetes.
For this purpose, the researchers analyzed post hoc data from the Exenatide Study of Cardiovascular Event Lowering (EXSCEL) trial. They compared participants who experienced MALE with those who did not. A multivariable model was constructed and translated into a risk score.
Participants were monitored for adverse events for the duration of the trial and a 90-day, post-trial follow-up period. Outcomes were assessed at clinical care visits at 1 week, 2 months, 6 months and every 6 months thereafter for the duration of the trial.
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