Scientists discover Novel Regenrative Treatment Path for Diabetic foot ulcer
Hippo signalling is an evolutionarily conserved pathway that restricts organ growth during development and suppresses regeneration in mature organs. In a recent study, researchers have discovered a novel molecule PY-60 that targets the ANXA2 protein. The researchers found by targeting ANXA2 protein, a druggable component of the Hippo pathway, the PY-60 drug were able to boost cell division and promote regenerative repair in chronic disease. The research has been published in the journal Nature Chemical Biology on March 15, 2021.
The transcriptional coactivator Yes-associated protein 1 (YAP) orchestrates a pro-proliferative transcriptional program that controls the fate of somatic stem cells and the regenerative responses of certain tissues. YAP is a major downstream effector of the Hippo intracellular signaling pathway, with key roles in organ development, regeneration, and cancer biology. A small molecule that targets Annexin (ANX) acts through YAP to promote rapid epidermal tissue expansion. Dr Michael J. Bollong and his team hypothesized that activation of YAP may hold therapeutic potential in disease states exacerbated by insufficient proliferative repair.
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