Semaglutide increases walking distance in diabetic patients with peripheral artery disease: Lancet
A new study published in The Lancet journal showed that patients with type 2 diabetes and symptomatic peripheral arterial disease were able to walk farther after using semaglutide. Few treatments help patients with lower limb peripheral artery disease enhance their functional ability and health-related quality of life. Therefore, Marc Bonaca and his team set out to determine if semaglutide improves symptoms, quality of life, and outcomes in individuals with peripheral vascular disease and type 2 diabetes, as well as function as indicated by walking ability.
In 20 countries throughout North America, Asia, and Europe, 112 outpatient clinical trial sites participated in the STRIDE study. The participants were of at least 18 year old who had peripheral artery disease, type 2 diabetes, intermittent claudication (Fontaine stage IIa, able to walk >200 m), and an ankle-brachial index of less than or equal to 0·90 or 0·70.
Using an interactive online response system, the participants were randomly randomized (1:1) to receive either a placebo or subcutaneous semaglutide 1·0 mg once weekly for 52 weeks. The ratio to baseline of the maximal walking distance at week 52, as determined by a constant load treadmill in the whole study set, served as the main endpoint.
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