Serum HDL level associated with HRV indices in patients with type 2 diabetes: Study
Hubballi, India: In patients with type 2 diabetes mellitus (T2DM), the HDL-C level and all other heart rate variability (HRV) indices are dependent on each other, findings from a recent study have suggested. The study was published in Diabetes Research and Clinical Practice on July 11, 2022.
The researchers further add that "most of these patients with low levels of HDL-C might be associated with autonomic imbalance; this is in turn detected by a simple bedside test of 1-minute HRV during deep breathing."
The study was conducted by Fareedabanu A. Balikai, Belgaum and KLE JGMM Medical College and Hospital, Hubballi, India, and colleagues with the objective to determine the correlation between serum HDL levels with HRV indices in patients with T2DM.
120 type 2 DM patients aged 35–65 years of either sex were included in the study by simple random sampling. One-minute HRV was analyzed during deep breathing and fasting serum HDL levels were estimated in all patients. SPSS 20.0 was used for the data analysis. For the assessment of the influence of independent variables (HRV Indices) on a dependent variable (serum HDL levels), Karl Pearson's correlation coefficient for relationship and Multiple linear regression analysis was applied.
Key findings include:
· Significant negative correlation was observed between serum HDL levels with Mean HR (r = 0.7422), LFnu (r = −0.6172) and ratio of LF/HF (r = 0.5333).
· Significant positive correlation was observed between serum HDL levels with HFnu (r = 0.6438), SDNN, (r = 0.7495), RMSSD (r = 0.6348) and pNN50 % (r = 0.8187).
"Our results suggest that in patients with diabetes, HDL-C level and all other HRV indices are dependent on each other," the researchers wrote.
"Most of these patients with low HDL-C levels might be associated with autonomic imbalance; this, in turn, is detected by a simple bedside test of 1-minute HRV during deep breathing."
Reference:
Balikai FA, Javali SB, Shindhe VM, Deshpande N, Benni JM, Shetty DP, Kapoor N, Jaalam K. Correlation of serum HDL level with HRV indices using multiple linear regression analysis in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract. 2022 Jul 11;190:109988. doi: 10.1016/j.diabres.2022.109988. Epub ahead of print. PMID: 35835257.
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