Serum Klotho has protective effect on postmenopausal Osteoporosis

A new study found that serum Klotho is an independent protective factor for postmenopausal women with osteoporosis. The study results were published in the journal BMC Endocrine disorders. 

Osteoporosis is a bone disorder affecting peri and postmenopausal women globally. A decrease in estrogen levels during menopause leads to accelerated bone loss affecting the safety of women's health. Klotho, a protein related to bone mineral density is found to affect the functioning of multiple organs. Previous literature showed that decreased klotho levels in blood were associated with high bone fragility. Hence researchers conducted a study to explore the relationship between serum klotho levels and osteoporosis in blood. 

 A retrospective study was carried out by collecting the data from 3 survey cycles in the National Health and Nutrition Examination Survey (NHANES) database, including 885 postmenopausal women over 50 years old. All participants underwent dual-energy X-ray absorptiometry examination and serum Klotho test at the time of the investigation. Logistic regression analysis was used to predict the risk model. P was used for trend and restricted cubic spline (RCS) was used to explore the nonlinear relationship between variables. 

Key findings: 

• Age, race, BMI, and Klotho are the influencing factors of osteoporosis.
• Klotho was found to be a protective factor.
• Based on the prediction model to evaluate the prediction ability, it was found that the prediction ability was good as C-index is 0.765. 
• P for trend was found to have a significant difference after adjusting the full variable.
• RCS showed that when Klotho concentration reached 824.09pg/ml, the risk of OP decreased significantly. 

Thus, the NHANES study found that Klotho is an independent protective factor for postmenopausal women with Osteoporosis and negatively correlated with the prevalence of osteoporosis. 

Further reading: https://doi.org/10.21203/rs.3.rs-2476910/v1 

Klotho Reduces the Risk of Osteoporosis in Postmenopausal Women: A cross-sectional Study of the National Health and Nutrition Examination Survey (NHANES)