SGLT-2i demonstrate lower risk for HF compared to metformin in type 2 diabetes patients
A population-based cohort study found that patients with type 2 diabetes receiving first-line sodium-glucose cotransporter-2 inhibitors (SGLT-2i) have a similar risk of stroke, myocardial infarction, and all-cause mortality but a lower risk of heart failure compared to patients receiving metformin. The authors also report that the risk for adverse events was similar except for an increased risk for genital infections among patients taking SGLT-2i. The findings are published in Annals of Internal Medicine.
SGLT-2i has demonstrated benefit in reducing risk of hospitalization in patients with cardiovascular disease (CVD). It has previously been recommended as a second-line treatment, but has more recently been recommended as a first-line treatment for patients with type 2 diabetes and CVD. Alternatively, metformin indicated reduced risk for myocardial infarction and all-cause mortality in a subgroup of patients in the U.K Prospective Diabetes Study.
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