SGLT2 Inhibitors Linked to Higher Erythrocytosis Risk Without Increasing Blood Clot Events in Type 2 Diabetes: JAMA
Israel: A new study published in JAMA Network Open highlights a key safety insight for patients with type 2 diabetes taking sodium-glucose cotransporter 2 inhibitors (SGLT2is). While these medications are linked to a higher risk of developing erythrocytosis, they do not appear to raise the likelihood of thrombotic events such as heart attacks, strokes, or blood clots.
The study, led by Dr. Maor Lewis from the Department of Family Medicine at Meuhedet Health Maintenance Organization in Tel-Aviv, Israel, analyzed data from over 269,000 adult patients with type 2 diabetes using records from Israel’s largest healthcare system. The research aimed to assess how frequently SGLT2is causes erythrocytosis—a condition characterized by elevated red blood cell levels—and whether this condition is associated with an increased risk of arterial or venous thrombosis.
Using a propensity score-matched design, the researchers compared new users of SGLT2is to those initiating either dipeptidyl peptidase 4 inhibitors (DPP-4is) or glucagon-like peptide 1 receptor agonists (GLP-1RAs). After matching, the final analysis included 68,776 patients in both the SGLT2i and DPP-4i groups and 65,756 in each of the SGLT2i and GLP-1RA groups.
Based on the study, the researchers reported the following findings:
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