SGLT2 Inhibitors May Lower Risk of Atopic Dermatitis in Diabetics: Study
Researchers have identified in a new study that sodium-glucose cotransporter-2 inhibitors (SGLT2i) could diminish the risk for the development of atopic dermatitis (AD) in patients with type 2 diabetes. Atopic dermatitis, characterized as a metabolic inflammatory skin condition, is recognized to have associations with the metabolic syndrome. Given SGLT2i’s ability to promote glucose and sodium excretion through urine, their impact on skin conditions has gained interest. The study was published in The British Journal of Dermatology by Yuan-Liang and colleagues.
https://doi.org/10.1093/bjd/ljaf086
This nationwide, active-comparator cohort study used data from the Taiwan National Health Insurance Database. Adult type 2 diabetes patients who started either SGLT2i or DPP4i between May 2016 and December 2018 were included, as long as they had no previous prescriptions for these drugs in the 12 months prior to recruitment. The study group consisted of 148,354 SGLT2i users, and the comparator group consisted of 322,703 DPP4i users. The main outcome was AD incidence, which was measured with Cox proportional hazards regression models. To control for confounders, inverse probability of treatment weighting (IPTW) was used to balance variables like baseline parameters, medical history, and prior medication use. Other analyses, such as sensitivity tests, subgroup analysis, and gender analysis, were also carried out for cross-validation.
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