Statins linked to initial increase in polyneuropathy risk in diabetes: Study
Denmark: Statin therapy does not mitigate or increase the risk of diabetic polyneuropathy (DPN) in type 2 diabetes (T2D) patients, according to a recent study in the journal Diabetes Care. However, during the first year, there was a slightly increased DPN risk among new users but it receded after >2 years of the study.
Owing to lipid-lowering and anti-inflammatory effects statins may reduce diabetic polyneuropathy (DPN) risk but also, their use has been associated with neurotoxicity. Frederik P. Kristensen, Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark, and colleagues examined whether statin therapy affects the risk of DPN.
The researchers identified all Danish patients with incident type 2 diabetes during 2002–2016. The initiation of statin in new users was done between 180 days before and 180 days after their first diabetes record. Prevalent users had initiated statins before that period. Patients were followed for incident diabetic polyneuropathy (DPN) using validated hospital diagnosis codes, starting 180 days after their first diabetes record
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