Statins lower risk of advanced liver fibrosis in diabetes patients: Study
Italy: Statin use lowers the risk of cirrhosis and advanced liver fibrosis in type 2 diabetes (T2D) patients, finds a recent study in the journal Metabolism: Clinical and Experimental. The lower risk was specifically seen in younger patients and women.
Type 2 diabetes patients are at increased risk of both advanced liver fibrosis related to non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD). Statin use is known to reduce the CVD incidence while evidence on its effect on NAFLD severity is limited. To fill this knowledge gap, Stefano Ciardullo and Gianluca Perseghin from Italy, performed a cross-sectional study performed using data from the 2017–2018 cycle of the National Health and Nutrition Examination Survey (NHANES).
It included adult patients with T2D and reliable vibration-controlled transient elastography (VCTE) results. Presence of liver fibrosis and steatosis were assessed by the median values of controlled attenuation parameter (CAP) and liver stiffness measurement (LSM) and, respectively. Patients with evidence of viral hepatitis and significant alcohol consumption were excluded.
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