Lipid Accumulation Product strongest Predictor of Diabetes Among Visceral Obesity Indices: Study

Key findings from the study include:

• All five visceral obesity indices were significantly associated with an elevated risk of developing diabetes, independent of other risk factors.
• LAP showed the strongest predictive value among all the indices assessed.
• The hazard ratio for LAP was 2.93, indicating that individuals with high LAP levels had nearly three times the risk of developing diabetes compared to those with lower values.
• RCS analysis revealed a nonlinear dose-response relationship between these indices and diabetes risk, suggesting a complex link between fat distribution and disease progression.
• Stratified and sensitivity analyses demonstrated the consistent predictive strength of LAP across various population subgroups.
• ROC curve analysis showed LAP had the highest predictive accuracy, with an area under the curve (AUC) of 0.752, reflecting a strong ability to identify high-risk individuals.

The study emphasizes the pivotal role of visceral fat in the pathogenesis of diabetes. It encourages healthcare professionals to consider visceral obesity indices, particularly LAP, when evaluating metabolic risk.

“The study reinforces the link between excess visceral fat and the onset of diabetes,” the authors noted. “It presents LAP as a simple and powerful tool for early identification of at-risk individuals, paving the way for more targeted prevention strategies to reduce visceral fat and mitigate the diabetes burden.”

Reference: https://doi.org/10.1111/dom.16492