Study Links ANGPTL 3 and 4 Proteins to Dyslipidemia in Type 2 Diabetes
Dyslipidemia, marked by abnormal cholesterol and triglyceride levels, remains a major health risk in developing countries and is worsened by poor glycemic control in T2DM. Researchers at the Kalinga Institute of Medical Sciences found in a case controlled study that angiopoietin-like proteins 3 and 4 (ANGPTL 3 and 4) are associated with dyslipidemia in patients with type 2 diabetes mellitus (T2DM).
Managing atherogenic lipid levels is therefore crucial to reducing the risk of complications. ANGPTL3 and ANGPTL4 are proteins known to regulate lipid metabolism by inhibiting lipoprotein lipase, an enzyme responsible for breaking down triglyceride-rich lipoproteins.
To investigate the role of these proteins, this study enrolled 61 T2DM patients aged 25 to 65 and 27 age-matched healthy controls. This research measured a wide range of biomarkers, including fasting blood sugar (FBS), postprandial blood sugar (PPBS), glycated hemoglobin (HbA1C) along with serum lipid parameters such as total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), high-density lipoprotein (HDL), and the TC/HDL ratio. They also assessed serum insulin, free fatty acids (FFA), and the levels of ANGPTL3 and ANGPTL4.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.