A recent study published in British Journal of Ophthalmology evaluated the effect of prediabetes and diabetes on macular thickness and retinal vascular calibres. The researchers found that, the prediabetes have an influence in the structure of the macula. According to the population-based study Prediabetes is associated with significant thinning of the macula and with decreases in...
A recent study published in British Journal of Ophthalmology evaluated the effect of prediabetes and diabetes on macular thickness and retinal vascular calibres. The researchers found that, the prediabetes have an influence in the structure of the macula.
According to the population-based study Prediabetes is associated with significant thinning of the macula and with decreases in retinal-artery diameters. These findings in early disease support the neurodegenerative theory in diabetes.
The findings of study underscore importance of controlling Blood sugar by lifestyle measures like diet control, exercise and Medicine use to prevent the complications.
The researchers conducted the study to evaluate the effect of prediabetes and diabetes on macular thickness and retinal vascular calibres in our population-based cohort (Northern Finland Birth Cohort).
It was a Northern Finland population based cohort study with 2005 subjects/ participants. They were divided into 3 groups.
57 with diabetes
1638 with prediabetes
310 with Normal glucose Metabolism
The diagnosis of diabetes and prediabetes was made according to WHO 2006 diagnostic standards.Researchers measured the total thickness of the macula using Cirrus HD-OCT 4000. Central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) calibres were examined from the fundus images.
The study results showed significant macular thinning (−2.69 μm) especially in pericenrtral area among prediabetic group. Macular cube average thickness (−0.10 mm3) and Macular cube volume also decreased significantly as glucose metabolism worsened. The researchers found that central retinal arteriolar equivalent (CRAE) decreased with an increase in diabetes measures.
The author stated " We detected significant thinning of the macula in subjects with prediabetes. The diameters of retinal arteries were decreased by impaired glucose metabolism"
Author further added "This study provides a new perspective since it revealed that the early and subtle changes caused by prediabetes as macular thinning had significant ACME (average causal mediation effect )on retinal vessels (CRVE and CRAE), therefore supporting the neurodegenerative theory of diabetes-induced changes in the retina."
For further information:
Disclaimer: This site is primarily intended for healthcare professionals. Any content/information on this website does not replace the advice of medical and/or health professionals and should not be construed as medical/diagnostic advice/endorsement/treatment or prescription. Use of this site is subject to our terms of use, privacy policy, advertisement policy. © 2024 Minerva Medical Treatment Pvt Ltd