Subcutaneous injection of oxytocin can reduce perception of heat pain, claims study
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A recent clinical trial provided strong evidence that subcutaneous injections of oxytocin which is often often associated with social bonding, to hold the key to manage certain types of pain locally without the risk of addiction associated with many pain medications. This study opens up avenues to treat pain in a targeted manner, specifically heat-related pain, without affecting sensitivity to other types of pain or altering the overall threshold for pain perception.
This randomized-controlled trial explored the localized effects of oxytocin on pain management. The trial involved 18 healthy adult participants who underwent two separate sessions where they received either a subcutaneous injection of synthetic oxytocin (4mcg/2ml) or a saline placebo in a double-blind setup.
The results revealed that participants reported a significant reduction in the intensity and unpleasantness of heat pain on the arm that received the oxytocin injection, as measured 10 minutes post-injection with a thermode. This effect was localized, with no comparable pain reduction observed in the contralateral arm, which confirms the action of oxytocin to be restricted around the area of injection site. The hormone did not significantly affect the perception of mechanical or pressure pain, and it did not alter the thresholds for heat pain perception.
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