TD2 patients with diabetic nephropathy have high risk of retinopathy

1. Among type 2 DM patients with DN, DR accounted for 61.4%, of which 23.6% had proliferative diabetic retinopathy (PDR) and 35.7% had sight-threatening DR.

2. The DR group had significantly higher scores for low-density lipoprotein cholesterol (LDL-C) (p =0.004), HbA1c (P =0.037), urinary albumin creatine ratio (ACR) (p <0.001), estimated thread Low degree of spherical filtration rate (eGFR) (P=0.013).

3. Logistic regression analysis showed that DR was significantly associated with ACR stage (p = 0.011).

4. ACR stage 3 subjects experienced DR more frequently than ACR stage 1 subjects.

5. HE and DME in 138 eyes of 138 patients were analyzed, of which 23.2% had posterior pole HE and 9.4% had DME.

6. Visual acuity in the HE group was worse than in the non-HE group.

7. There were significant differences in LDL-C cholesterol, total cholesterol (CHOL), and ACR between HE and non-HE groups.

In summary, patients with DN require more timely and frequent ophthalmologic examinations.

Reference:

Yan, Y., Yu, L., Sun, C., Zhao, H., Zhang, H., & Wang, Z. (2023). Retinal microvascular changes in diabetic patients with diabetic nephropathy. In BMC Endocrine Disorders (Vol. 23, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1186/s12902-022-01250-w