Tiny silica particles can stop fat tissue accumulation leading to diabetes, obesity treatment

Sweden: Engineered ingestible molecular traps created from mesoporous silica particles (MSPs) introduced to the gut can have an effect on food efficiency and metabolic risk factors. The results from studies on mice, published in Nanomedicine, demonstrate the potential to reduce the energy uptake into the body and could lead to new treatments for obesity and diabetes.

So far there are no effective treatments for obesity that hinder weight gain or promote weight loss without problematic side effects. Many of the current medications use small pharmacological agents that can affect the body negatively in multiple ways.

"We chose an innovative alternative approach. Mesoporous silica particles (MSP) are a type of ingestible synthetic silica particles that can be produced with a large surface area and a range of pore sizes", says professor Tore Bengtsson at the Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University and the one heading the research team behind the study.

The team hypothesized that the particles could be used as "molecular sieves" in the intestine to trap and block digestive enzymes that break down food and thus reduce the energy uptake into the body (measured as food efficiency).