Triglyceride-glucose index valuable for early diagnosis of metabolic syndrome: Study
China: Triglyceride-glucose (TyG) index is of great importance in the early diagnosis of metabolic syndrome (MS), says a recent study in the International Journal of Endocrinology. The study showed associations between the TyG index and MS and its components.
Metabolic syndrome and its components such as hypertension, overweight or obesity, hyperlipidemia, hyperglycemia, stroke, and atherosclerosis are important risk factors for cardiovascular diseases (CVDs). The components are independently or jointly related. Although there is substantial evidence on the relationship between MS and vascular diseases -- as well as the relationships between dyslipidemia, hypertension, and diabetes, and the TyG index, there is no published report on the relationship between the TyG index and MS.
Against the above background, Yufeng Wen, Department of Prevention Medical, School of Public Health, Wannan Medical College, Wuhu, China, and colleagues conducted a study to explore the relationship between the triglyceride-glucose index and metabolic syndrome in a cross-sectional study.
For this purpose, 298,652 individuals with an average age of 47.08 ± 12.94 years and who underwent health check-ups at the First Affiliated Hospital of Wuhu Wannan Medical College were enrolled from 2014 to 2016. 125,025 women (41.86%) and 173,627 men (58.14%) were enlisted. The survey information included a physical examination, a questionnaire survey, and a laboratory examination.
Based on the study, the researchers found the following:
- The prevalence of MS increased gradually in the TyG-index subgroups (Q1, TyG <8.30; Q2, 8.30≤ TyG <8.83; and Q3, TyG ≥8.83).
- Significant differences were noted in hypertension, hyperlipidemia, hyperglycemia, sex, age, body mass index (BMI), smoking and drinking habits, and estimated glomerular filtration rate between the TyG-index subgroups.
- Multiclass logistic regression analysis showed that the group with TyG <8.30 was the reference group, and the 8.30≤ TyG <8.83 and the TyG ≥8.83 groups exhibited a higher TyG index with MS, and a lower TyG index without MS disease.
- In the linear curve analysis of the TyG index and MS components, BMI, systolic blood pressure, and diastolic blood pressure showed upward trends, while high-density lipoprotein cholesterol showed no obvious trend in the TyG index at a range of 7.8-11.0.
- Receiver operating characteristic analysis was used to evaluate the predictive value of the TyG index, triglycerides, and fasting blood glucose for MS, and the authors found that the area under the TyG index curve was the largest (AUC = 0.89).
The researchers concluded that there is an association between the TyG index and MS and its components. The TyG index manifested great value in the early diagnosis of MS. This suggested that in a population with a significantly increased TyG index, it is necessary to identify and control multiple metabolically related risk factors.
Reference:
Mingfei Jiang, Xiaoran Li, Huan Wu, Fan Su, Lei Cao, Xia Ren, Jian Hu, Grace Tatenda, Mingjia Cheng, Yufeng Wen, "Triglyceride-Glucose Index for the Diagnosis of Metabolic Syndrome: A Cross-Sectional Study of 298,652 Individuals Receiving a Health Check-Up in China", International Journal of Endocrinology, vol. 2022, Article ID 3583603, 9 pages, 2022. https://doi.org/10.1155/2022/3583603
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