Troponin and D-dimer significant predictors of pulmonary embolism in T2DM, reveals study

Written By : Aditi

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2024-04-27 04:15 GMT | Update On 2024-04-27 10:48 GMT

Type 2 diabetes mellitus (T2DM) is a condition characterized by a prothrombotic, proinflammatory, and hypofibrinolytic state. However, the relationship between T2DM and pulmonary embolism (PE) remains unclear. PE is a common cardiovascular disease that can have serious clinical consequences. Despite this, many patients at risk for PE are not identified in routine clinical practice.

According to a recent study published in
Medicinski Glasnik, the presence of T2DM in patients with pulmonary embolism is tied to a greater risk of mortality and complications. Identifying risk factors is crucial for reducing this risk. Troponin, D-dimer, prothrombotic, and proinflammatory markers help predict short-term outcomes for these patients.

The study examines the connection between T2DM and pulmonary embolism and determines the prognostic value of troponin, D-dimer, prothrombotic, and proinflammatory markers in patients with T2DM. There were 305 patients with pulmonary embolism, including 165 with T2DM and 140 without (control group). Data were collected from May 2018 to May 2023, and various parameters were analyzed.

Key findings from this study are:

T2DM patients showed elevated troponin, D-dimer, CRP, uric acid, fibrinogen, and HOMA-IR, and they experienced more severe complications and higher mortality rates within ten days of hospital admission.
Significant predictors of PE in T2DM patients were found. Troponin and D-dimer were significant predictors of PE in type 2 diabetes mellitus. These patients also had significantly higher waist circumference and BMI.
PE patients with T2DM had higher total cholesterol, LDL cholesterol, triglycerides, and glucose and lower HDL cholesterol.
PE patients with T2DM had a 4.38 times higher chance of death compared to those with pulmonary embolism without T2DM.

The results show notable associations and point to potential risk factors for these patient populations. Our findings suggest that measuring troponin values in patients with pulmonary embolism and T2DM could help distinguish high- and intermediate-risk patients from low-risk ones, in line with previous studies. This could make troponin a valuable tool for risk assessment and early detection of PE in this group.

The two major limitations addressed include a small cohort from a single centre, more focus on laboratory markers and a small sample size.

Reference:

Bošnjić, Jasmina. "Prediction of Pulmonary Embolism and Its Complication in Diabetes Mellitus Type 2: a 5-year Retrospective Study." Medicinski Glasnik : Official Publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina, vol. 21, no. 1, 2024, pp. 36-44.

Article Source : Medicinski Glasnik

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Aditi

Dr. Aditi Yadav is a BDS, MDS in Periodontics and Implantology. She has a clinical experience of 5 years as a laser dental surgeon. She also has a Diploma in clinical research and pharmacovigilance and is a Certified data scientist. She is currently working as a content developer in e-health services. Dr. Yadav has a keen interest in Medical Journalism and is actively involved in Medical Research writing.

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Troponin and D-dimer significant predictors of pulmonary embolism in T2DM, reveals study

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