Tryptophan and serotonin levels, a new approach for early diagnosis of diabetes complications?

Key takeaways from the study:

• The 5-HT level can be considered a potent biomarker for the early detection of DM complications.
• It was also proved that outside the digestive and central nervous systems, 5-HT was discovered in beta cells, and scientists have been attempting to realize its mechanism of action ever since.
• Towards the end, the determination methods, biomarker's role, and approaches of 5-HT and Trp levels were thoroughly investigated in both healthy and diabetic patients with or without complications.
• The association between insulin and 5-HT has been specifically discussed.
• In most cases, increases in 5-HT and insulin levels have been observed simultaneously in beta cells.

Based on the study, the authors conclude, "Trp and 5-HT levels could be exclusively applied for early diagnosis of DM complications as well as many other complications." 

Reference:

Khoshnevisan, K., Chehrehgosha, M., Sajjadi-Jazi, S.M. et al. Tryptophan and serotonin levels as potent biomarkers in diabetes mellitus complications: a new approach of diagnostic role. J Diabetes Metab Disord (2022). https://doi.org/10.1007/s40200-022-01096-y