Type 2 Diabetes Linked to Increased Asthma Risk, Regardless of Genetic Susceptibility: Longitudinal Study Finds
China: A recent longitudinal study published in BMC Public Health has shed light on a significant association between type 2 diabetes (T2D) and the risk of developing asthma, independent of an individual’s genetic predisposition.
The comprehensive study leveraging UK Biobank data has revealed that individuals with type 2 diabetes face a 16% higher risk of developing asthma, with a hazard ratio (HR) of 1.16. This increased risk was consistently observed across individuals with high and low genetic susceptibility. The research, which followed 388,775 participants over a median period of 13.6 years, demonstrated that the association between T2D and asthma remained significant even after adjusting for variables such as age, sex, smoking status, and genetic predisposition.
The researchers note that the prevalence of type 2 diabetes and asthma is on the rise, but limited evidence exists regarding the link between these conditions, particularly when considering genetic predispositions. To address this gap, Bo Zhang, Department of Endocrinology, China-Japan Friendship Hospital, Hepingli, Chaoyang District, Beijing, China, and colleagues conducted an observational analysis to investigate the association between T2D and asthma. This study incorporated genetic susceptibility to asthma, assessed using a polygenic risk score (PRS), to provide a comprehensive understanding of the relationship.
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