Type 2 diabetes tied to hepatic fibrosis risk in people with obesity and NAFLD: Study
USA: A recent study published in the journal Obesity has suggested a link between diabetes and diabetes plus obesity to a higher risk of moderate to advanced fibrosis. The results showed that the majority of diabetes patients, even those in the early stages of obesity had steatosis and a high prevalence of fibrosis.
People with diabetes or obesity with increased alanine aminotransferase or steatosis are said to be at high risk for steatohepatitis with advanced liver fibrosis (nonalcoholic steatohepatitis fibrosis) and cirrhosis. However, the knowledge is derived largely from the selected population and has not yet been observed in a large cohort in the general population. The interaction and/or added risk of having both obesity and diabetes for fibrosis development remains unclear.
Against the above background, Kenneth Cusi, Division of Endocrinology, Diabetes and Metabolism, University of Florida, Gainesville, Florida, USA, and colleagues aimed to assess the impact of diabetes on nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) with advanced fibrosis prevalence in overweight/obese people in the United States.
The study included 834 middle-aged patients with DM (21.7%) and 3,007 without DM (78.3%) from the National Health and Nutrition Examination Survey [NHANES] 2015-2016 database. NAFLD was defined by Fatty Liver Index (FLI) ≥ 60 or United States FLI (USFLI) ≥ 30.
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