Earlier studies have found that T1DM adolescents vitamin D deficiency coincided with poor blood sugar control and disturbed body composition. 25(OH)D levels were positively related to muscle stores and negatively with fat stores. Therefore it was recommended that vitamin D deficiency should be corrected by implementation of regular vitamin D supplementation and increased intake of vitamin D-rich foods, as well as increased outdoors activities.
Vitamin D is produced in skin in response to direct sunlight . It is also found in small amounts in some foods such as oily fish as well as foods fortified with vitamin D such as dairy products, breakfast cereal, and orange juice . Most foods are not a great source of vitamin D necessitating intake of Vitamin D supplementation to boost vitamin D levels.
Dr Raquel Segovia-Ortí at Pediatrics, Son Espases University Hospital, Palma, Spain and associates conducted a study to evaluate whether Vitamin D blood levels at onset of type 1 diabetes mellitus (T1DM) would influence analytical variables of worse prognosis of the disease at the beginning and after one year of development.
The investigators conducted a retrospective study of pediatric patients (0–14 years) diagnosed with T1DM with initial measurements of blood levels of vitamin D was performed at Son Espases Hospital, between March 2012 and April 2019 (n=67).
They found that Vitamin D insufficiency was related to age, blood sugar control,glycosylated hemoglobin, and creatinine. An improvement in blood sugar and glycosylated hemoglobin was found in subjects whose baseline serum 25(OH)D was >30 ng/mL. Bivariate correlation analysis adjusted by age showed a significantly positive correlation of vitamin D with pH , bicarbonate , and free levothyroxine . Independent variables associated with vitamin D insufficiency were age and winter season .
They concluded that Hypovitaminosis D is related to biochemical variables showing greater severity and higher glycosylated hemoglobin at diagnosis: higher creatinine, lower free levothyroxine, pH, and bicarbonate. Unsupplemented patients with baseline deficiency showed persistently worse blood sugar control compare to those with baseline repletion.
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