Vitamin D deficiency tied to dyslipidemia in type 2 diabetes complicated with obesity and CAD: Study

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2022-10-22 07:00 GMT | Update On 2022-10-22 10:33 GMT

Saudi Arabia: In type 2 diabetes, the deficiency status of vitamin D was shown to be associated with dyslipidemia, particularly those complicated with coronary artery diseases and obesity, a recent study in Clinical Laboratory has revealed.

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease leading to vascular complications. Amal F. Gharib, Taif University, Ta'if, Saudi Arabia, and colleagues aimed to investigate the relationship between vitamin D deficiency, dyslipidemia, and obesity with the risk of coronary artery disease in type 2 diabetes.

The study included 200 Saudi adult participants, aged 40 - 60 years, of both genders, who attended King Abdulaziz Specialist Hospital in Taif city. The subjects were categorized into four groups; the control group, type 2 diabetes, type 2 diabetes with coronary artery disease (CAD), and type 2 diabetes with obesity having body mass index (BMI) ≥ 30 kg/m2; 50 subjects were included in each group.

The researchers estimated fasting blood glucose (FBG), serum vitamin D (25-OH-D), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), glycosylated hemoglobin (HbA1c), and triglycerides (TG) levels.

The study led to the following findings:

Serum vitamin D and HDL-C in the three diabetic patient groups were significantly decreased compared to the control group.
Among patient groups, the levels in the diabetic coronary and diabetic obese patients were significantly decreased compared to the diabetic patient group.
FBG levels, HbA1c%, TC, TG, LDL-C levels, and BMI in all diabetic patient groups were significantly higher compared to the control.
Significant negative correlations were observed between serum vitamin D and FBG, HbA1c%, TC, TG, LDL-C levels, and BMI, whereas positive correlations with HDL-C in all diabetic patient groups.

The researchers concluded that "the deficiency status of 25-OH-D is linked with dyslipidemia in type 2 Saudi diabetic patients, particularly those complicated with obesity and coronary artery diseases."

Reference:

Gharib, Amal F., et al. "Association of Vitamin D Deficiency, Dyslipidemia, and Obesity With the Incidence of Coronary Artery Diseases in Type 2 Diabetic Saudi Patients." Clinical Laboratory, vol. 68, no. 10, 2022.

Article Source : Clinical Laboratory

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Dr Kartikeya Kohli

Dr Kartikeya Kohli is an Internal Medicine Consultant at Sitaram Bhartia Hospital in Delhi with super speciality training in Nephrology. He has worked with various eminent hospitals like Indraprastha Apollo Hospital, Sir Gangaram Hospital. He holds an MBBS from Kasturba Medical College Manipal, DNB Internal Medicine, Post Graduate Diploma in Clinical Research and Business Development, Fellow DNB Nephrology, MRCP and ECFMG Certification. He has been closely associated with India Medical Association South Delhi Branch and Delhi Medical Association and has been organising continuing medical education programs on their behalf from time to time. Further he has been contributing medical articles for their newsletters as well. He is also associated with electronic media and TV for conduction and presentation of health programs. He has been associated with Medical Dialogues for last 3 years and contributing articles on regular basis.

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Vitamin D deficiency tied to dyslipidemia in type 2 diabetes complicated with obesity and CAD: Study

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