SURMOUNT-5 Trial: Tirzepatide vs Semaglutide in Obesity Management
The SURMOUNT-5 trial evaluated the efficacy and safety of tirzepatide compared to semaglutide in adults with obesity or overweight with at least one related complication, but without diabetes. Obesity is now recognized as a chronic, progressive, and relapsing disease, with global prevalence expected to reach 1.9 billion by 2030¹⁻³. While lifestyle interventions such as diet and...
Both treatments showed safety profiles consistent with previous studies, with gastrointestinal events being the most common. Overall, tirzepatide demonstrated superior efficacy in weight reduction and related outcomes compared to semaglutide.
THERAPEUTIC INDICATION¹⁰:
Type 2 diabetes mellitus
• as monotherapy when metformin is considered inappropriate due to intolerance or contraindications
• in addition to other medicinal products for the treatment of diabetes.
Weight management
• ≥ 30 kg/m² (obesity) or
• ≥ 27 kg/m² to < 30 kg/m² (overweight) in the presence of at least one weight-related comorbid condition (e.g., hypertension, dyslipidaemia, obstructive sleep apnoea, cardiovascular disease, prediabetes, or type 2 diabetes mellitus).
For Tirzepatide Prescribing Information, please check: https://image.mc.lilly.com/lib/fe9312747462077971/m/1/0e04e051-5fa2-445b-850d-4f09ef66d35e.pdf
REFERENCES
1. Kelly T, et al. Int J Obes. 2008;(32):1431-1437.
2. NCD Risk Factor Collaboration. Lancet. 2024;403(10431):1027-1050.
3. World Obesity Federation. https://data.worldobesity.org/publications/?cat=23. Accessed July 27, 2025.
4. Apovian CM, et al. J Clin Endocrinol Metab. 2015;100(2):342-362.
5. Hall KD, et al. Med Clin North Am. 2018;102(1):183-197.
6. Fruh SM. J Am Assoc Nurse Pract. 2017;29(S1):S3-S14.
7. Ansari WE, et al. Obes Surg. 2021;31:1755-1766.
8. SURMOUNT-5. ClinicalTrials.gov identifier: NCT05822830. https://clinicaltrials.gov/ct2/show/NCT05822830. Updated December 11, 2024. Accessed February 13, 2025.
9. Aronne LJ, et al. N Engl J Med. 2025;393(1):26-36.
10. Mounjaro®(tirzepatide), India Prescribing Information. Updated March 2025.
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CMAT-24202 | 14 April 2026
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