Adequate intakes of folate, vitamin B6, and vitamin B12 reduces incident MetS: JAMA

The associations of B vitamin status with metabolic syndrome (MetS) incidence among the US population remain unclear. A study was done to investigate intakes and serum concentrations of folate, vitamin B6, and vitamin B12 in association with MetS risk in a large US cohort.

This prospective study included Black and White young adults in the US who were enrolled from 1985 to 1986 and studied until 2015 to 2016. Diet was assessed using a validated diet history at examination years 0, 7, and 20. Serum concentrations of folate, vitamin B6, and vitamin B12 were assayed at examination years 0, 7, and 15 in a subset of 1430 participants. MetS was ascertained by clinic and laboratory measurements and self-reported medication use. Data were analyzed between January and July 2021.

Multivariable Cox proportional hazards regression models were used to calculate hazard ratios (HRs) and 95% CIs for the associations of energy-adjusted B vitamin intakes or serum B vitamin levels with incident MetS.

This prospective cohort study found that intakes and serum concentrations of folate, vitamin B6, and vitamin B12 were inversely associated with incident MetS among Black and White young adults in the US.

Reference:

Zhu J, Chen C, Lu L, Shikany JM, D’Alton ME, Kahe K. Folate, Vitamin B6, and Vitamin B12 Status in Association With Metabolic Syndrome Incidence. JAMA Netw Open. 2023;6(1):e2250621. doi:10.1001/jamanetworkopen.2022.50621

Keywords:

JAMA Netw Open, Metabolic Syndrome Incidence, Zhu J, Chen C, Lu L, Shikany JM, D’Alton ME, Kahe K. Folate, Vitamin B6, and Vitamin B12