Curcumin can be used as a novel approach to improving lipid profile: Study

Several meta-analyses exist supporting the beneficial effects of curcumin supplementation on lipid profile parameters; however, some studies findings are inconsistent. Therefore, the current umbrella of meta-analysis of clinical trials was performed to evaluate the findings of multiple meta-analyses on the efficacy of curcumin on lipid profiles in adults.

A comprehensive systematic search of PubMed/Medline, Scopus, Embase, Web of Science and Google Scholar was carried out up to May 2022 (in English only). The random-effects model was employed to conduct a meta-analysis. The quality assessment of the selected meta-analyses was measured using a measurement tool to assess multiple systematic reviews (AMSTAR). Of 101 articles returned in the literature search, 19 articles met the qualifications for inclusion in the umbrella meta-analysis.

The results are:

• The results revealed that the curcumin supplementation was effective on reducing of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) levels
• Beyond that, Curcumin intake significantly increased high-density lipoprotein cholesterol (HDL-C) levels

Thus, Curcumin has ameliorating effects on TC, TG, LDL-c, and HDL-c levels. Overall, Curcumin could be recommended as an adjuvant anti-hyperlipidemic agent.

Reference:

Vali Musazadeh et al. Curcumin as a novel approach in improving lipid profile: An umbrella meta-analysis. Nutrition, Metabolism and Cardiovascular Diseases. Published: August 06, 2022DOI:https://doi.org/10.1016/j.numecd.2022.07.021

Keywords:

Vali Musazadeh, Neda Roshanravan, Mehdi Mohammadizadeh, Zeynab Kavyani, Parvin Dehghan, Erfan Mosharkesh, Curcumin, novel approach, improving, lipid, profile, umbrella, meta-analysis, Nutrition, Metabolism and Cardiovascular Diseases