Omega-3 Fatty Acids May Lower Atopic Dermatitis Risk: Study
Researchers have found in a new study that higher plasma omega-3 levels are linked to a reduced risk of atopic dermatitis (AD), regardless of genetic predisposition. These findings suggest that increasing omega-3 consumption could serve as a preventive strategy against the condition. The study was published in the Molecular Research & Food Nutrition journal by Rui Mao and fellow researchers.
AD is an inflammatory skin disorder with both genetic and environmental etiology. Data from the UK Biobank were used in the study to assess the influence of fatty acid levels on the risk of AD, particularly with elderly-onset. The research also examined whether genetic susceptibility was influencing this connection. Plasma omega-3 levels were measured and participants were segregated based on genetic risk profiles. The research focused on genetic variants rs1692120 and rs174448, which have been associated with AD susceptibility. Hazard ratios (HRs) with 95% confidence intervals (CIs) were computed to establish the association between levels of omega-3, genetic risk, and AD occurrence.
Key Findings
• Increased plasma levels of omega-3 were linked with decreased AD risk (HR: 0.93; 95% CI: 0.89-0.98), reflecting a protective effect.
• Both high levels of omega-3 and low genetic risk were related to the lowest AD risk, reflecting a 38% decrease in risk as compared to the reference group.
• Individuals with the GA/AA genotype on rs1692120 had a significantly increased risk of AD, whereas those with more A alleles on rs174448 had a significantly lower risk (both p<0.05).
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