Omega-3 supplementation significantly reduces homocysteine levels, lowering CVD risk: Study
Tehran, Iran: Omega 3 supplementation significantly improves plasma homocysteine (Hcy) levels, show results from a meta-analysis. Further studies however will be needed to confirm the findings. The study was published in Nutrition, Metabolism and Cardiovascular Diseases on May 21, 2022.
The results of the analyses demonstrated that compared to the control group, omega 3 supplementations significantly reduced plasma Hcy levels (WMD: -1.34 μmol/L). In addition, the supplementation during the < 12 weeks intervention and with a dose of ≥ 3 gr per day resulted in a greater decrease in Hcy levels than the intervention ≥12 weeks and at a dose of < 3 gr.
Some evidence has suggested that the supplementation of omega-3 polyunsaturated fatty acids (PUFAs) influences enzymes involved in homocysteine formation and improves hyperhomocysteinemia. However, these findings are still contradictory in humans. Azita Hekmatdoost, Shahid Beheshti University of Medical Sciences, Tehran, Iran, and colleagues, therefore, aimed to examine the effects of omega 3 supplementation on Hcy using existing randomized controlled trials (RCTs) in a systematic and meta-analysis study.
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