Rising IL-18 levels linked to decreased carbohydrates tolerance in body

In this study, 387 Caucasians were separated into four groups: prediabetic patients, newly diagnosed type 2 diabetics, obese subjects without carbohydrate difficulties, and healthy controls.

The key findings of this study were as follows:

1. In comparison to the control group (219.47 ± 110.53 pg/ml), subjects with a body mass index of 30 kg/m2 and glycemic problems had significantly higher levels of IL-18 (249.77 ± 89.96 pg/ml, 259.01 ± 95.70 pg/ml, and 340.98 ± 127.65 pg/ml).

2. Additionally, whereas IL-18 was negatively correlated with HDL, it had substantial favorable relationships with a number of anthropometric measurements, liver enzymes, fasting glucose, insulin, uric acid, and triglycerides.

3. By using ROC analysis, it was possible to distinguish between participants with carbohydrate problems and those who had metabolic syndrome based on their circulating levels of IL-18.

4. The AUC for changes in glucose metabolism was 0.597, while the AUC for MS was 0.581.

Further research is necessary to determine the role of IL-18 in the development of diabetes mellitus and its effects concluded the Authors.

Reference:

Nedeva, I., Gateva, A., Assyov, Y., Karamfilova, V., Hristova, J., Yamanishi, K., Kamenov, Z., & Okamura, H. (2022). IL-18 Serum Levels in Patients with Obesity Prediabetes and Newly Diagnosed Type 2 Diabetes. Iranian Journal of Immunology, 19(2). https://doi.org/10.22034/iji.2022.90095.1987