Vitamin C supplementation may help reduce inflammatory response, myocardial injury and mortality in sepsis patients: Study

A recent study delves into the therapeutic potential of vitamin C in sepsis, shedding light on its efficacy in reducing inflammatory responses and myocardial injury. This study was published in the journal of Alternative Therapies In Health and Medicine by Jiang N. and colleagues.

Conducted on 83 sepsis patients, this study aimed to assess the impact of vitamin C supplementation on inflammatory response and myocardial damage. Patients were randomly divided into a control group receiving basic treatment and a study group receiving vitamin C in addition to basic treatment. Various parameters including organ dysfunction, inflammatory markers, myocardial injury indices, and morbidity/mortality rates were evaluated before and after treatment.

• The study revealed significant improvements in the study group compared to the control group.

• After therapy, the study group exhibited lower Sequential Organ Failure Assessment (SOFA) scores, indicating reduced organ dysfunction.

• Levels of inflammatory markers such as Hypersensitive C-reactive Protein (hs-CRP), Tumor Necrosis Factor (TNF), and High Mobility Group Protein B1 (HMGB1) were significantly lower in the study group post-treatment.

• Moreover, indices of myocardial injury including Creatine Kinase Isoenzyme (CK-MB), Troponin I (cTnI), and B-type brain natriuretic peptide (BNP) were markedly reduced in the study group.

• Importantly, the study group demonstrated a lower morbidity and mortality rate compared to the control group, further emphasizing the therapeutic benefits of vitamin C supplementation in sepsis.

The study underscores the significant therapeutic value of vitamin C supplementation in sepsis management. By attenuating inflammatory responses, reducing myocardial injury, and improving clinical outcomes, vitamin C emerges as a promising adjunctive therapy for sepsis. These findings pave the way for future strategies aimed at enhancing patient care and mitigating sepsis-related complications.

Reference:

Jiang, N., Li, N., Huang, J., Ning, K., Zhang, H., Gou, H., & Zhang, R. Impact of vitamin C on inflammatory response and myocardial injury in sepsis patients. Alternative Therapies in Health and Medicine,2024. https://pubmed.ncbi.nlm.nih.gov/38401077/