Vitamin C supplementation may help reduce inflammatory response, myocardial injury and mortality in sepsis patients: Study

• The study revealed significant improvements in the study group compared to the control group.

• After therapy, the study group exhibited lower Sequential Organ Failure Assessment (SOFA) scores, indicating reduced organ dysfunction.

• Levels of inflammatory markers such as Hypersensitive C-reactive Protein (hs-CRP), Tumor Necrosis Factor (TNF), and High Mobility Group Protein B1 (HMGB1) were significantly lower in the study group post-treatment.

• Moreover, indices of myocardial injury including Creatine Kinase Isoenzyme (CK-MB), Troponin I (cTnI), and B-type brain natriuretic peptide (BNP) were markedly reduced in the study group.

• Importantly, the study group demonstrated a lower morbidity and mortality rate compared to the control group, further emphasizing the therapeutic benefits of vitamin C supplementation in sepsis.

The study underscores the significant therapeutic value of vitamin C supplementation in sepsis management. By attenuating inflammatory responses, reducing myocardial injury, and improving clinical outcomes, vitamin C emerges as a promising adjunctive therapy for sepsis. These findings pave the way for future strategies aimed at enhancing patient care and mitigating sepsis-related complications.

Reference:

Jiang, N., Li, N., Huang, J., Ning, K., Zhang, H., Gou, H., & Zhang, R. Impact of vitamin C on inflammatory response and myocardial injury in sepsis patients. Alternative Therapies in Health and Medicine,2024. https://pubmed.ncbi.nlm.nih.gov/38401077/