Off-label use of otic ciprofloxacin/dexamethasone led to hyperglycemia in infant: Case report
USA: A recent case report, published in the Annals of Otology, Rhinology & Laryngology, describes the case of hyperglycemia in a child with Type 1 diabetes following the off-label use of otic ciprofloxacin/dexamethasone drops in the nasal passage. The article also reviews previous reports of adverse endocrine effects from intranasal corticosteroids in pediatric patients.
Tom Ben-Dov, New York University School of Medicine, New York, NY, USA, and colleagues describe the clinical case and conducted a literature review of MEDLINE (PubMed) and EMBASE.
The case in question is of a 9-month-old female with a history of Type 1 diabetes who underwent unilateral choanal atresia repair and was started on 1 week of ciprofloxacin 0.3%/dexamethasone 0.1% otic drops twice a day for choanal obstruction with granulation tissue.
While the patient's airway patency improved, average daily blood glucose increases by 40 to 50 points were noted on the patient's continuous glucose monitor. The hyperglycemia resolved within 2 days after switching to mometasone furoate 0.05% spray.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.