Rare case of Melkersson-Rosenthal Syndrome treated with 5-fluorouracil- A report
David M. Alessi and colleagues from the Alessi Institute, Los Angeles, CA, USA recently reported an interesting case of Melkersson-Rosenthal syndrome, or orofacial granulomatosis where the patient was treated with 5-fluorouracil and responded positively.
The report is published in the Ear, Nose and Throat Journal.
The rarity of Melkersson-Rosenthal syndrome, or orofacial granulomatosis, can present with persistent midface bogginess. The management for previous reported cases has included corticosteroid injections, antihistamines, and antibiotics.
Chronic orofacial edema can result from a multitude of etiologies, such as those of an infectious, inflammatory, or allergic origin, among others. A proper history intake, as well as thorough physical examination, can inform the clinician both as to the cause and the most appropriate and efficacious management approach.
The authors studied the report of a 45-year-old male presented with welts under his eyes with associated thickening of the buccal space of 8 months duration. The patient presented with no significant past medical history aside from occasional hay fever, had no history of trauma or surgery, and denies any pertinent social or family history.
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