Recommendations for Care of Survivors of Head and Neck Cancer: JAMA Clinical Guidelines Synopsis

Most recurrences occur in the first few years after treatment. The National Comprehensive Cancer Network (NCCN) recommends integration of primary care in survivorship care within 1 year of completion of treatment, complementary to the oncology team. There has been an increased focus and maturation of the concept of cancer survivorship since previous efforts.

The current guidelines offer a concise summary of best practices for this integrated care. Characteristics of the Guideline Source The American Head and Neck Society exists to "advance education, research, and quality of care for the head and neck oncology patient" and is the largest organization of its kind in North America. The guideline group was composed of surgical, radiation, and medical oncologists. No funding conflicts were reported. Evidence Base More than half of head and neck cancer survivors are current smokers; 50% continue to smoke after diagnosis, and there is evidence that current smoking increases mortality in oropharyngeal cancer, even when controlling for HPV status.

A third of head and neck cancer patients consume more than 3 alcoholic drinks per day, a behavior linked to increased risk of recurrence and depression and other substance use disorders. Prolonged opioid use after treatment has been associated with current tobacco use and history of alcohol abuse. The guideline recommends referring these patients for tobacco and alcohol cessation counseling, citing systematic reviews that evaluated cessation programs in this population. Effective pharmacologic agents include nicotine replacement therapy and varenicline, ideally combined with multiple sessions of behavior therapy.

Patients treated for HPV-associated head and neck cancer should be educated about the role of vaccination in prevention of other HPV associated cancers and offered treatment for associated guilt, anxiety, and concerns about sexual behaviors. The emotional and physical stress on patients with head and neck cancer through diagnosis, treatment, and surveillance can be immense, and greater than that experienced by other cancer survivors.

Rates of suicidality are twice that of other patients with cancer, triple that of the general US population, and increasing. Given this, regular screening for body image disturbance, distress, depression, and anxiety with validated instruments such as the NCCN Distress Thermometer, Patient Health Questionnaire or others is strongly recommended in this population.

The guideline authors note that mental and emotional health support is often underused and early referral to psychiatry/psychology is recommended. High rates of chronic pain and long-term opioid dependence further complicate care. Screening with validated instruments should be accompanied by multimodal analgesia plans and pain management, when appropriate. Issues stemming from dysphagia, effects of treatment on dentition, and lymphedema may all negatively affect quality of life and self-image. Close follow-up with speech therapy, dental professionals, and physical therapy are all recommended (level of evidence 2A, 1B, and 2A, respectively).

Hypothyroidism occurs in a third to nearly half of patients who receive radiation to their neck, often as a late sequela, and can have a role in depression and wound healing. In patients who have undergone irradiation of the neck, regular evaluation for thyroid dysfunction by measuring thyrotropin and thyroxine is recommended. Patients who have undergone extensive neck surgery are at risk of inadvertent injury to the thyroid or its blood supply and should also be screened. The high pretreatment and posttreatment prevalence of tobacco use in patients surviving head and neck cancer also increases risk of primary lung cancer. Analysis of the National Lung Screening Trial (NLST) found that patients with history of head and neck cancer and a heavy smoking history had significantly higher rates of lung cancer vs smokers without a similar history of head and neck cancer. The majority of these patients already qualify for lung cancer screening under current guidelines and would likely receive greater benefit from screening relative to the general smoking population.

Robust communication between oncology teams and primary care clinicians is paramount to successful care of head and neck cancer survivors. As the frequency of visits with the oncology teams decreases after the first year, it becomes particularly important that primary care clinicians are aware of sequelae of treatment, the screening and treatment recommendations in these guidelines, and the importance of identifying symptoms concerning for recurrence or second primary cancers. Primary care clinicians should also facilitate regular patient followup with an otolaryngologist/head and neck surgeon for head and neck–specific examination, even in the absence of concerning symptoms. Early detection of new odynophagia, otalgia, neck mass, or other concerning findings or symptoms should prompt early return to the oncology team for further evaluation. Other age-and sex-appropriate screening and preventive care can be overlooked after a cancer diagnosis but remains important in survivors of head and neck cancer.

Primary care clinicians have a critical role in the management of patients who survive head and neck cancer. Awareness of the signs and symptoms suspicious for recurrence is critical for timely referral and intervention, as recurrence can often be treated with curative salvage therapy. These cancers may recur at the primary site, locoregionally as a new neck mass, or as a distant metastasis. Rates of recurrence vary depending on the primary tumor characteristics, treatment modality, and primary site. The 5-year overall survival in patients with stage I-II disease is currently 70% to 90% but is poorer in patients with stage III-IV disease. As an example, patients with locoregionally advanced laryngeal carcinoma are reported to have an approximate overall survival of 40% at 5 years.

These guidelines represent important outreach to clinicians who provide care for these patients outside of cancer-focused contexts. Ongoing efforts to support prevention and early recognition of HNSCC are crucial to reducing the overall burden of this disease on patients and should include efforts to improve general access to care, HPV vaccination in teens and young adults, and education to support patient and clinician recognition of earlier cancer. Approaches such as navigation-based multilevel interventions have shown promise in delivering timely, guideline-adherent therapy and reducing race disparities, and deserve further study.

Source: Samuel Auger; Andrew Davis; Ari J. Rosenberg, JAMA Clinical Guidelines Synopsis doi:10.1001/jama.2022.17064