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Antibody deficiencies common in adults with recurrent acute rhinosinusitis, Study reveals

Written By :  Dr. Nandita Mohan
Medically Reviewed By :  Dr. Kamal Kant Kohli
Published On 2021-04-05 21:00 GMT   |   Update On 2021-04-06 09:21 GMT

According to the researchers from the Departments of Otolaryngology, West Virginia University School of Medicine, Morgantown, WV, USA, it has been highlighted that Humoral immunodeficiency, specifically SAD, seems to be more common in adult versus pediatric RARS, as published in the American Journal of Otolaryngology.Chadi A.Makary and associates carried out the present study with the purpose...

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According to the researchers from the Departments of Otolaryngology, West Virginia University School of Medicine, Morgantown, WV, USA, it has been highlighted that Humoral immunodeficiency, specifically SAD, seems to be more common in adult versus pediatric RARS, as published in the American Journal of Otolaryngology.

Chadi A.Makary and associates carried out the present study with the purpose to evaluate the frequency and types of humoral immunodeficiencies (HID) in pediatric and adult patients with recurrent (RARS). Patients with HID commonly present with upper respiratory tract infections. Their pathophysiology in children is different than adult counterparts. It is unknown how HID affects those two age groups.


The authors performed a retrospective chart review of pediatric (
3 times/year) rhinosinusitis. Patients with cystic fibrosis, Aspirin Exacerbated Respiratory Disease (AERD), and ciliary dyskinesia were excluded.

Demographic data and associated conditions were reviewed. Immunologic evaluation included complete blood cell count (CBC) with differential, serum immunoglobulin G, A, and M levels, and baseline and post-vaccination pneumococcal antibody titers.
The results showed that –
There were 135 patients who met the inclusion criteria.
86 patients (63.7%) were children, 49 patients (36.3%) were adults.
46.5% of the pediatric patients and 45% of the adult patients were female.
17.4% of children had abnormal immunologic findings: 8 had hypogammaglobulinemia (p < 0.0001), 2 had specific antibody deficiency (SAD), and 5 had selective IgA deficiency. 32.7% of adults (p < 0.0001) had abnormal immunologic findings: 4 had hypogammaglobulinemia, 11 had SAD (p < 0.0001), and 1 patient had both IgA deficiency and SAD.
It was then concluded that "humoral immunodeficiency, specifically SAD, seems to be more common in adult versus pediatric RARS that is refractory to treatment."


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Article Source : American Journal of Otolaryngology

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Dr. Nandita Mohan

Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

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