Blood Eosinophil Count Key Indicator of Inflammatory Severity in chronic rhinosinusitis with nasal polyps: Study
Taiwan: A recent study published in The Laryngoscope has revealed blood eosinophil count (BEC) has become a key clinical marker for assessing the severity of type 2 inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP). It demonstrated the strongest correlation with both tissue eosinophil count and type 2 cytokine levels in nasal polyps.
Comorbid asthma, nonsmoking status, and the ethmoid/maxillary sinus ratio were significant predictors of eosinophilic CRSwNP. These findings highlight the role of BEC in evaluating disease severity and identifying patients at higher risk for more severe forms of the condition.
Severe type 2 eosinophilic chronic rhinosinusitis with nasal polyps (CRSwNP) is difficult to treat and prone to recurrence after surgery. To address this, Chien-Chia Huang, School of Medicine, Chang Gung University, Taoyuan, Taiwan, and colleagues aimed to assess the relationship between clinical markers and the severity of tissue type 2 inflammation in patients with CRSwNP.
For this purpose, the researchers prospectively enrolled adult patients who underwent endoscopic sinus surgery for bilateral CRSwNP. They evaluated the tissue eosinophil count (TEC) and measured the expression levels of type 2 cytokines, including IL-5 and IL-13, in nasal polyps using real-time PCR. The study also assessed the correlations between clinical markers and the severity of tissue type 2 inflammation.
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