The study was led by Jerome R. Lechien, MD, PhD, from the University of Mons in Belgium. It examined 33 patients who had lost their sense of smell following head trauma. After receiving PRP injections into the nasal area, two-thirds of patients reported improvements in their ability to smell, with significant objective improvements measured at three months.
"This groundbreaking study is the first worldwide to demonstrate that platelet-rich plasma injection into the olfactory clefts can significantly improve smell recovery in post-traumatic patients-sometimes several years after the trauma," said Dr. Lechien. "To date, there is no effective treatment for smell loss following head trauma. This novel treatment offers new hope for head trauma patients suffering from persistent smell loss, a condition that profoundly impacts quality of life and safety."
The study found that 67% of patients who received PRP treatment reported subjective improvement after a single injection. Psychophysical testing revealed significant increases in smell scores, achieving clinically meaningful improvements that were superior to olfactory training alone. On average, patients detected their first recovered odors within 5.4 weeks after treatment.
The study included patients who had been experiencing smell loss for an average of nearly five years (55 months), suggesting that even long-standing cases may benefit from treatment.
Why This Matters
Losing the sense of smell after a head injury affects far more than just enjoying food. It impacts safety (detecting gas leaks or smoke), emotional well-being, and quality of life.
Studies indicate that 5%-30% of patients who experience head trauma suffer from smell loss.
Between 17% and 27% of people who lose their sense of smell after head trauma may experience some natural recovery, but many face permanent loss with limited treatment options-until now. Only approximately 10% of patients recover some olfactory function through smell training protocols alone.
About the Treatment
PRP therapy involves using a patient's own blood plasma, which is rich in growth factors that promote healing and tissue regeneration. The treatment is injected into the olfactory cleft-the area in the upper nose responsible for detecting smells.
While these results are preliminary and based on a small group of patients, they represent the first investigation of PRP effectiveness specifically for trauma-related smell loss. Dr. Lechien notes that larger randomized controlled trials are needed to confirm these findings.
Reference:
Jerome R. Lechien, Platelet-Rich Plasma for Posttraumatic Olfactory Dysfunction: Preliminary Report of 33 Patients, Otolaryngology, https://doi.org/10.1002/ohn.1358
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.